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Heterochromia

 

Definition

Heterochromia is the presence of different colored eyes in the same person.

Alternative Names

Differently colored eyes; Eyes - different colors

Common Causes

Most cases of heterochromia are hereditary, caused by a disease or syndrome, or due to an injury. Sometimes one eye may change color following certain diseases or injuries.

Specific causes of eye color changes include:

  • Bleeding (hemorrhage)
  • Familial heterochromia
  • Foreign object in the eye
  • Glaucoma, or some medications used to treat it
  • Injury
  • Mild inflammation affecting only one eye
  • Neurofibromatosis
  • Waardenberg syndrome
Home Care

Call your health care provider if

Consult your health care provider if you notice new changes in the color of one eye, or two differently colored eyes in your infant. A thorough eye examination is needed to be sure this isn't a symptom of a medical problem.

Some conditions and syndromes associated with heterochromia, such as pigmentary glaucoma, can only be detected by a thorough eye exam.

What to expect at your health care provider's office

Your health care provider may ask the following questions to help evaluate the cause:

  • Did you notice the two different eye colors when the child was born, shortly after the birth, or recently?
  • Are any other symptoms present?

An infant with heterochromia should be examined by both a pediatrician and an ophthalmologist for other possible problems.

A complete eye examination can rule out most causes of heterochromia. If there doesn't seem to be an underlying disorder, no further testing may be necessary. If another disorder is suspected, diagnostic tests, such as blood tests or chromosome studies, may be done to confirm the diagnosis.

Considerations

Heterochromia is uncommon in humans, but quite common in dogs (such as Dalmatians and Australian sheep dogs), cats, and horses.

References

Olitsky SE, Hug D, Smith LP. Abnormalities of pupil and iris. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 621.


Review Date: 11/2/2009
Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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