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Roseola is an acute disease of infants and young children in which a high fever and skin rash occur.

Alternative Names

Exanthem subitum; Sixth disease


The disease is common in children ages 3 months to 4 years, and most common in those ages 6 months to 1 year. It is caused by a virus called human herpesvirus 6 (HHV-6), although similar syndromes are possible with other viruses.

Roseola occurs throughout the year. The time between becoming infected and the beginning of symptoms (incubation period) is 5 to 15 days.


The child may have a runny nose, sore throat, and eye redness.

A fever usually occurs before the rash appears. It lasts for 3 (sometimes up to 7) days. The fever may be as high as 105° Fahrenheit, and it generally responds well to acetaminophen (Tylenol).

Between the second and fourth day of the illness, the fever drops and a rash appears (often as the fever falls).

  • The rash starts on the trunk and spreads to the limbs, neck, and face. The rash is pink or rose-colored, and has fairly small sores that are slightly raised.
  • The rash lasts from a few hours to 2-3 days. It usually does not itch.

Other symptoms include:

Signs and tests
  • Physical exam of rash
  • Swollen lymph nodes on the neck (cervical nodes) or back of the scalp (occipital nodes)
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Expectations (prognosis)

Most children with roseola fully recover.

Calling your health care provider

Call your health care provider if your child:

  • Has a fever that does not go down with acetaminophen (Tylenol) or ibuprofen (Advil) and a warm bath
  • Continues to appear very sick
  • Acts irritable or lethargic

Go to the emergency room or call the local emergency number (such as 911) if your child has convulsions.


There is no specific treatment. The disease usually gets better without complications.

Take steps to control a fever with acetaminophen (Tylenol) and cool sponge baths. If convulsions occur, call your health care provider, or go to the closest emergency room.


The viruses that cause roseola are spread either through fecal-oral contact or via airborne droplets. Careful handwashing can help prevent the spread of these viruses.


Leach CT. Roseola (Human Herpesviruses 6 and 7). In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier;2007: chap 253.

Review Date: 11/2/2009
Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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