Kaposi's sarcoma is a cancerous tumor of the connective tissue, and is often associated with AIDS.
Before the AIDS epidemic, Kaposi's sarcoma was seen mainly in elderly Italian and Jewish men, and rarely, in elderly women. Among this group, the tumors developed slowly. In AIDS patients, the cancer can develop very fast. It may also involve the skin, lungs, gastrointestinal tract, and other organs.
In people with AIDS, Kaposi's sarcoma is caused by an interaction between HIV, a weakened immune system, and the human herpesvirus-8 (HHV-8). Kaposi's sarcoma has been linked to the spread of HIV and HHV-8 through sexual activity.
People who have kidney or other organ transplants are also at risk for Kaposi's sarcoma.
African Kaposi's sarcoma is fairly common in young adult males living near the equator. One form is also common in young African children.
The tumors appear as bluish-red or purple sores (lesions) on the skin. The color comes from the fact that they are rich in blood vessels.
The lesions may first appear on the feet or ankles, thighs, arms, hands, face, or any other part of the body. They also can appear on sites inside the body.
Other symptoms may include:
The following tests may be performed to diagnose Kaposi's sarcoma:
Treating Kaposi's sarcoma does not improve the chances of survival from AIDS itself. The outlook depends on the person's immune status and how much of the HIV virus is in the patient's blood (viral load).
Complications can include:
- Cough and shortness of breath (if the disease is in the lungs)
- Leg swelling that may be painful or cause infections (if the disease is in the lymph nodes of the legs)
The tumors can return even after treatment. Kaposi's sarcoma can be fatal for a person with AIDS.
An aggressive form of African Kaposi's sarcoma can spread quickly to the bones. Another form found in African children does not affect the skin. Instead, it spreads through the lymph nodes and vital organs, and can quickly become fatal.
How this condition is treated depends on:
- How much the immune system is suppressed (immunosuppression)
- Number and location of the lesions
Lesions may return after treatment.
Safe sexual practices can prevent HIV infection. This prevents AIDS and its complications, including Kaposi's sarcoma.
Volberding PA. Hematology and oncology in patients with human immunodeficiency virus infection. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 416.
Review Date: 9/28/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Jatin M. Vyas, MD, PhD, Instructor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2009 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.